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Olfactory Receptor family 51 subfamily E member 1.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI VRTEHSLHEP MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL 

       110        120        130        140        150        160        170        180        190        200 
LQMFAIHSLS GMESTVLLAM AFDRYVAICH PLRHATVLTL PRVTKIGVAA VVRGAALMAP LPVFIKQLPF CRSNILSHSY CLHQDVMKLA CDDIRVNVVY 

       210        220        230        240        250        260        270        280        290        300 
GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG TCVSHVCAVF IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI 

       310        320 
RQRILRLFHV ATHASEP

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   

L P S D  R H V M  V R I D     I F   Q I T T      W F  A E E L  
 I V P    S L G    V V N   V P L P   A D F    I A L    W F Q   
I N A L  I F P V  I L G Y   A M L   Q L L C  M K P M  P F A L  
 L L Y    Y F I    I I V   A A G R   A F M    S S T    S C L   
V P P V  F V A C  G I A S   V V A   L S H I  S I L I  I L Y L  
 P N L    V H S    S D L   A V G I   M G S    D I G    L V A   
G Y V I  V C T G  S I L L   K T V   V T S E  S L M C  T L N G  
     V    F A K    Y S F   R P L T   A L L    L F I    Y I I   
         A Q A E  L I L L           D F A M  Y M P E  T R V I  
                   V T K             V Y R                 E   
                    L G L             C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards | ORDB
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
butyric acid -5.47 1 10 1  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
3-methylvaleric acid -5.47 2 10 2  animal, sharp, acidic, cheesy, green, fruity, sweaty
isovaleric acid -4.82 3 10 3  cheesy, sour, sweaty, tropical
pelargonic acid -5.3 3 8 3  cheesy, dairy, dirty, waxy
valeric acid -4.74 2 8.07 2  acidic, cheesy, fruity, milky, sharp, sour, tobacco
4-methylvaleric acid -5.21 2 6.86 2  cheesy, pungent
cyclobutane carboxylic acid -4.6 2 7.78 2  
caproic acid -4.52 3 6.49 3  cheesy, fatty, sour, sweaty
5-norbornene-2-carboxylic acid - 6.85 2  fruity, green
butyl butyryl lactate -3.47 4 7 4  creamy, buttery, buttermilk, dairy, cheesy, fatty, waxy, sweaty, green
propionic acid -4.97 2 3.52 2  acidic, cheesy, pungent, vinegar
2-methylvaleric acid -3.3 2 5.63 2  cheesy, sour
oenanthic acid - 4.85 2  rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity
2-decenoic acid - 4.52 2  fatty
2-methylbutanoic acid -1.78 2 6.17 2  pungent, acidic, cheesy, roquefort, fruity, dirty, fermented
caprylic acid - 4.42 2  cheesy, fatty, oily, rancid, vegetable, waxy
norbornane-2-carboxylic acid -2.3 5 4.2353 5  
3-methyl-2-hexenoic acid -4.22 6 0.48 6  cheesy, fruity
cyclohexanecarboxylic acid -1.87 5 4.1176 5  fruity, acidic, metallic, cheesy, tropical
capric acid - 3.51 2  citrus, fatty, rancid, sour
2-nonenoic acid - 3.43 2  fatty, oily
4-methyl nonanoic acid - 3.4 2  meaty, pork, lamb, chicken, fatty, goaty
cyclopropanecarboxylic acid -1.3 5 1.1765 5  
methyl eugenol - 1.1667 7  carnation, cinnamon, clove, fresh, spicy, sweet, warm
(1S,2R,5S)-(+)-menthol - 0.7 7  cooling, mentholic, minty
methyl salicylate - 0.7 7  minty, wintergreen
eugenyl acetate - 0.6 7  carnation, clove, floral, fresh, malty, spicy, sweet, woody
2,4-DNT - 0.5 7  
pyrazine - 0.5 7  pungent, sweet, corn, roasted, hazelnut, barley
dimethyl disulfide - 0.4333 7  sulfurous, vegetable, cabbage, onion, malty, creamy
delta-decalactone - 0.4167 1  coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet
methyl furfuryl disulfide - 0.4 7  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
n-amyl alcohol - 0.3333 4  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
propanal - 0.3333 7  alcoholic, cocoa, earthy, nutty, whisky, winey
acetophenone - 0 4  sweet, pungent, hawthorn, mimosa, almond, acacia, chemical
allyl heptanoate - 0 4  sweet, pineapple, fruity, waxy, banana, fusel, cognac, ripe, fermented
allyl phenylacetate - 0 7  honey, fruity, rummy
allylbenzene - 0 4  
amyl hexanoate - 0 7  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 7  animal, musky
l-arabinose - 0 7  
benzene - 0 7  gasoline, phenolic, solvent, cinnamon
benzoic acid - 0 8  balsamic, urine
benzophenone - 0 4  balsamic, rose, metallic, powdery, geranium, herbal, plastic, phenolic
benzyl acetate - 0 4  sweet, floral, fruity, jasmine, fresh
bornane-2-carboxylic acid - 0 5  
butyl formate - 0 7  fruity, plum, rummy, brandy
(-)-camphor - 0 4  
camphor - 0 4  camphorous
gamma-caprolactone - 0 4  herbal, coconut, sweet, coumarinic, tobacco, creamy, lactonic, green
(R)-(-)-carvone - 0 4  herbal, minty, spearmint, sweet
(S)-(+)-carvone - 0 7  bready, caraway, minty, spicy
4-chromanone - 0 4  
citral - 0 7  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
citric acid - 0 8  
(S)-(-)-citronellol - 0 4  citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
coffee difuran - 0 7  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
2-coumaranone - 0 4  
coumarin - 0 7  coumarinic, hay, sweet, tonka
cyclohexanone - 0 4  acetone, minty
beta-damascone - 0 7  berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - 0 7  sweet, aldehydic, waxy, orange_peel, citrus, floral
1-decanol - 0 8  aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy
diacetyl - 0 1  buttery, caramellic, creamy, pungent, sweet
(+)-dihydrocarvone - 0 4  herbal, minty, mentholic
dihydrojasmone - 0 4  floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody
2-ethyl fenchol - 0 7  camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl isobutyrate - 0 4  alcoholic, ethereal, fruity, fusel, rummy, sweet
ethyl vanillin - 0 7  sweet, creamy, vanilla, caramellic
eugenol - 0 7  clove, spicy, sweet, woody
fenchone - 0 4  camphorous, earthy, herbal, woody
geraniol - 0 4  citrus, floral, fruity, rose, sweet, waxy
geranyl acetate - 0 7  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
helional - 0 7  cyclamen, fresh, green, hay, ozone, watery
heptanal - 0 4  aldehydic, cognac, fatty, fresh, green, herbal, ozone
1-heptanol - 0 4  musty, leafy, violet, herbal, green, sweet, woody, peony, pungent, vegetable, fruity, apple, banana
2-heptanone - 0 7  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
3-heptanone - 0 4  fatty, fruity, green
hexanal - 0 4  aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty
2,3-hexanedione - 0 4  buttery, sweet
3,4-hexanedione - 0 4  almond, buttery, caramellic, nutty, toasted
hexanol - 0 8  ethereal, fusel, oily, fruity, alcoholic, sweet, green, pungent, apple_skin
2-hexanone - 0 4  ethereal
(Z)-3-hexen-1-ol - 0 7  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
hexyl acetate - 0 4  apple, banana, fruity, green, sweet
4-hydroxycoumarin - 0 4  
isobutylamine - 0 7  cheesy, fishy
lauric acid - 0 8  bay, coconut, fatty
d-limonene - 0 7  citrus, orange, fresh, sweet
linalool - 0 7  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
lyral - 0 7  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
myristic acid - 0 8  citrus, coconut, fatty, peel, pineapple, soapy, waxy
nonanal - 0 7  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
nonanethiol - 0 4  
1-nonanol - 0 7  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
2-nonanone - 0 4  fresh, sweet, green, weedy, earthy, herbal, fruity, waxy, soapy, cheesy, coconut, dairy, dirty, buttery
octanal - 0 4  aldehydic, citrus, fatty, green, orange, peel, waxy
octanethiol - 0 7  sulfurous
1-octanol - 0 8  aldehydic, green, mushroom, orange, rose, waxy
2-octanone - 0 4  earthy, herbal, natural, weedy, woody
3-octanone - 0 4  fresh, herbal, lavender, mushroom, sweet
octyl octanoate - 0 7  coconut, oily, fruity
palmitic acid - 0 8  creamy, fatty, waxy
2-pentanone - 0 4  sweet, fruity, ethereal, winey, banana, woody, fermented
phenyl acetate - 0 4  phenolic, medicinal, animal, resinous, castoreum, woody, smoky, burnt
(+)-2-phenylbutyric acid - 0 4  
prenyl acetate - 0 4  sweet, fresh, banana, fruity, jasmine, ripe, heliotrope, balsamic
quinoline - 0 7  earthy, medicinal, musty, rubbery, tobacco
sotolone - 0 7  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 7  bergamot, citrus, herbal, lavender, lime
vanillic acid - 0 4  beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla
citronellal - -0.9091 3  sweet, dry, floral, herbal, waxy, aldehydic, citrus
2-cyclohexylpropanal - -0.9091 3  natural, fresh, green, dusty, fruity
hydroxycitronellal - -0.9091 3  floral, green, lily, melon, sweet, tropical, waxy
bourgeonal - -1.8182 3  fresh, watery, floral, cyclamen, sweet
florhydral - -1.8182 3  floral, green, muguet, linden_flower, lily_of_the_valley, fresh
7-methoxycitronellal - -1.8182 3  fresh, melon, floral, lily, sweet

1.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.

2.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.

3.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2

4.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.

5.) Pierre Chatelain, Alex Veithen, Francoise Wilkin, and Magali Philippeau Deorphanization and Characterization of Human Olfactory Receptors in Heterologous Cells Chem Biodivers. 2014 Nov;11(11):1764-81. doi: 10.1002/cbdv.201400083. PMID: 25408322.

6.) Aya Kato, Naoko Saito (2018) Search method for odor control agent JP6422665B2

7.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

8.) YOSHIFUMI FUJITA, TOMOKO TAKAHASHI, AKIKO SUZUKI, KAYO KAWASHIMA, FUTOSHI NARA & RYUTA KOISHI (2007) Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor, Journal of Receptors and Signal Transduction, 27:4, 323-334, DOI: 10.1080/10799890701534180
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