Olfactory Receptor family 51 subfamily E member 1.
Sequence:
10 20 30 40 50 60 70 80 90 100 MVDPNGNESS ATYFILIGLP GLEEAQFWLA FPLCSLYLIA VLGNLTIIYI VRTEHSLHEP MYIFLCMLSG IDILISTSSM PKMLAIFWFN STTIQFDACL 110 120 130 140 150 160 170 180 190 200 LQMFAIHSLS GMESTVLLAM AFDRYVAICH PLRHATVLTL PRVTKIGVAA VVRGAALMAP LPVFIKQLPF CRSNILSHSY CLHQDVMKLA CDDIRVNVVY 210 220 230 240 250 260 270 280 290 300 GLIVIISAIG LDSLLISFSY LLILKTVLGL TREAQAKAFG TCVSHVCAVF IFYVPFIGLS MVHRFSKRRD SPLPVILANI YLLVPPVLNP IVYGVKTKEI 310 320 RQRILRLFHV ATHASEP
Transmembrane Helices:
TMR1 TMR2 TMR3 TMR4 TMR5 TMR6 TMR7 E E L G I A L A D F Q F V R I D S L G L P S D F Q A M K P M L L C V P L P V V N I F P I V P F A L W S S T A F M Q A M L I L G Y V Y F I I N A L C L P S I L I S H I A A G R I I V F V A L L Y L Y L S D I G M G S L V V A G I A S C V H S V P P V V A I S L M C T S E A V G I S D L V C T P N L L N G L L F I A L L V K T V S I L L G F A K G Y V I I I T Y M P E F A M R P L T Y S F A Q A K V R V I Y V Y R D L I L L E R T L C I A V T K H G L UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
| Odorant | EC50 | Adjusted Top | Antagonist? | Aroma Notes |
|---|---|---|---|---|
| butyric acid | -5.47 1 | 10 2 | acetic, buttery, cheesy, fruity, sharp | |
| 3-methylvaleric acid | -5.47 2 | 10 3 | acidic, animal, cheesy, fruity, green, sharp, sweaty | |
| isovaleric acid | -4.82 4 | 10 5 | cheesy, sour, sweaty, tropical | |
| pelargonic acid | -5.3 1 | 8 6 | cheesy, dairy, dirty, waxy | |
| valeric acid | -4.74 2 | 8.07 2 | acidic, cheesy, fruity, milky, sharp, sour, tobacco | |
| 4-methylvaleric acid | -5.21 2 | 6.86 2 | cheesy, pungent | |
| cyclobutane carboxylic acid | -4.6 2 | 7.78 2 | ||
| caproic acid | -4.52 7 | 6.49 2 | cheesy, fatty, sour, sweaty | |
| 5-norbornene-2-carboxylic acid | - | 6.85 2 | ||
| butyl butyryl lactate | -3.47 6 | 7 6 | buttermilk, buttery, cheesy, creamy, dairy | |
| propionic acid | -4.97 4 | 3.52 2 | acidic, cheesy, pungent, vinegar | |
| 2-methylvaleric acid | -3.3 3 | 5.63 2 | cheesy, sour | |
| oenanthic acid | - | 4.85 2 | rancid, sour, cheesy, sweaty, waxy, fermented, pineapple, fruity | |
| 2-decenoic acid | - | 4.52 2 | fatty | |
| 2-methylbutanoic acid | -1.78 5 | 6.17 2 | acidic, cheese, cheesy, dirty, fermented, fruity, pungent, roquefort | |
| caprylic acid | - | 4.42 2 | cheesy, fatty, oily, rancid, vegetable, waxy | |
| norbornane-2-carboxylic acid | -2.3 5 | 4.2353 5 | ||
| 3-methyl-2-hexenoic acid | -4.22 8 | 0.48 8 | cheesy, fruity | |
| cyclohexanecarboxylic acid | -1.87 5 | 4.1176 5 | fruity, acidic, metallic, cheesy, tropical | |
| capric acid | - | 3.51 2 | citrus, fatty, rancid, sour | |
| 2-nonenoic acid | - | 3.43 2 | fatty, oily | |
| 4-methyl nonanoic acid | - | 3.4 2 | meaty, pork, lamb, chicken, fatty, goaty | |
| cyclopropanecarboxylic acid | -1.3 5 | 1.1765 5 | ||
| methyl eugenol | - | 1.1667 9 | carnation, cinnamon, clove, fresh, spicy, sweet, warm | |
| (+)-menthol | - | 0.7 9 | cooling, mentholic, minty | |
| methyl salicylate | - | 0.7 9 | minty, wintergreen | |
| eugenyl acetate | - | 0.6 9 | carnation, clove, floral, fresh, malty, spicy, sweet, woody | |
| 2,4-DNT | - | 0.5 9 | ||
| pyrazine | - | 0.5 9 | pungent, sweet, corn, roasted, hazelnut, barley | |
| dimethyl disulfide | - | 0.4333 9 | cabbage, onion, sulfurous, vegetable | |
| delta-decalactone | - | 0.4167 10 | coconut, creamy, dairy, fatty, fresh, fruity, lactonic, milky, oily, peach, sweet | |
| methyl furfuryl disulfide | - | 0.4 9 | alliaceous, coffee, meaty, roasted, sulfurous | |
| pentanol | - | 0.3333 9 | balsamic, fermented, fusel, oily, sweet | |
| propanal | - | 0.3333 9 | alcoholic, cocoa, earthy, nutty, whiskey, winey | |
| acetophenone | - | 0 6 | sweet, pungent, hawthorn, mimosa, almond, acacia, chemical | |
| aldehyde C-10 | - | 0 9 | aldehydic, citrus, floral, orange, peel, sweet, waxy | |
| aldehyde C-8 | - | 0 6 | aldehydic, citrus, fatty, green, orange, peel, waxy | |
| aldehyde C-9 | - | 0 9 | aldehydic, fatty, fresh, orange, orris, peel, peely, rose, waxy | |
| allyl heptanoate | - | 0 6 | banana, cognac, fruity, fusel, pineapple, sweet, waxy | |
| allyl phenylacetate | - | 0 9 | fruity, honey, rummy | |
| allylbenzene | - | 0 6 | ||
| amyl hexanoate | - | 0 9 | apple, estery, fatty, fruity, green, pear, pineapple, sweet | |
| androstenone | - | 0 9 | animal, musky | |
| l-arabinose | - | 0 9 | ||
| benzene | - | 0 9 | ||
| benzoic acid | - | 0 3 | balsamic, urine | |
| benzophenone | - | 0 6 | balsamic, geranium, herbal, metallic, powdery, rose | |
| benzyl acetate | - | 0 6 | floral, fresh, fruity, jasmine, sweet | |
| bornane-2-carboxylic acid | - | 0 5 | ||
| butyl formate | - | 0 9 | brandy, fruity, plum, rummy | |
| (-)-camphor | - | 0 6 | ||
| camphor | - | 0 6 | camphoraceous | |
| gamma-caprolactone | - | 0 6 | coconut, coumarinic, herbal, sweet, tobacco | |
| caramel furanone | - | 0 9 | burnt, caramellic, coffee, maple, sugar, sweet | |
| (R)-(-)-carvone | - | 0 6 | herbal, minty, spearmint, sweet | |
| (S)-(+)-carvone | - | 0 9 | bready, caraway, minty, spicy | |
| 4-chromanone | - | 0 6 | ||
| citral | - | 0 9 | citrus, lemon, sharp, sweet | |
| citric acid | - | 0 3 | ||
| (S)-(-)-citronellol | - | 0 6 | citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy | |
| coffee difuran | - | 0 9 | cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty | |
| 2-coumaranone | - | 0 6 | ||
| coumarin | - | 0 9 | coumarinic, hay, sweet, tonka | |
| cyclohexanone | - | 0 6 | acetone, minty | |
| beta-damascone | - | 0 9 | berry, currant, floral, fruity, honey, plum, rose, tobacco | |
| 1-decanol | - | 0 3 | aldehydic, clean, fatty, floral, green, orange, sweet, tart, watery, waxy | |
| diacetyl | - | 0 10 | buttery, caramellic, creamy, pungent, sweet | |
| (+)-dihydrocarvone | - | 0 6 | herbal, mentholic, minty | |
| dihydrojasmone | - | 0 6 | floral, fresh, herbal, jasmine, myrrh, outdoors, spicy, woody | |
| 2-ethyl fenchol | - | 0 9 | camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea | |
| ethyl isobutyrate | - | 0 6 | alcoholic, ethereal, fruity, fusel, rummy, sweet | |
| ethyl vanillin | - | 0 9 | caramellic, creamy, sweet, vanilla | |
| eugenol | - | 0 9 | clove, spicy, sweet, woody | |
| fenchone | - | 0 6 | camphoraceous, earthy, herbal, woody | |
| geraniol | - | 0 6 | citrus, floral, fruity, rose, sweet, waxy | |
| geranyl acetate | - | 0 9 | floral, green, lavender, rose, waxy | |
| helional | - | 0 9 | cyclamen, fresh, green, hay, ozone, watery | |
| heptanal | - | 0 6 | aldehydic, cognac, fatty, fresh, green, herbal, ozone | |
| 1-heptanol | - | 0 6 | apple, banana, fruity, green, herbal, leafy, musty, peony, pungent, sweet, vegetable, violet, woody | |
| 2-heptanone | - | 0 9 | banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody | |
| 3-heptanone | - | 0 6 | fatty, fruity, green | |
| hexanal | - | 0 6 | aldehydic, fatty, fresh, fruity, grass, green, leafy, sweaty | |
| 2,3-hexanedione | - | 0 6 | buttery, sweet | |
| 3,4-hexanedione | - | 0 6 | almond, buttery, caramellic, nutty, toasted | |
| 1-hexanol | - | 0 3 | alcoholic, ethereal, fruity, fusel, green, herbal, oily, pungent, sweet | |
| 2-hexanone | - | 0 6 | ethereal | |
| cis-3-hexen-1-ol | - | 0 9 | foliage, fresh, grassy, green, herbal, oily, vegetable | |
| hexyl acetate | - | 0 6 | apple, banana, fruity, green, sweet | |
| 4-hydroxycoumarin | - | 0 6 | ||
| isobutylamine | - | 0 9 | cheesy, fishy | |
| lauric acid | - | 0 3 | bay, coconut, fatty | |
| d-limonene | - | 0 9 | citrus, fresh, orange, sweet | |
| linalool | - | 0 9 | blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody | |
| lyral | - | 0 9 | aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody | |
| myristic acid | - | 0 3 | citrus, coconut, fatty, peel, pineapple, soapy, waxy | |
| nonanethiol | - | 0 6 | ||
| 1-nonanol | - | 0 9 | aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet | |
| 2-nonanone | - | 0 6 | earthy, fresh, fruity, green, herbal, sweet, weedy | |
| octanethiol | - | 0 9 | sulfurous | |
| 1-octanol | - | 0 3 | aldehydic, green, mushroom, orange, rose, waxy | |
| 2-octanone | - | 0 6 | earthy, herbal, natural, weedy, woody | |
| 3-octanone | - | 0 6 | fresh, herbal, lavender, mushroom, sweet | |
| octyl octanoate | - | 0 9 | coconut, fruity, oily | |
| palmitic acid | - | 0 3 | creamy, fatty, waxy | |
| 2-pentanone | - | 0 6 | banana, ethereal, fruity, sweet, winey, woody | |
| phenyl acetate | - | 0 6 | animal, burnt, castoreum, medicinal, phenolic, resinous, smoky, woody | |
| (+)-2-phenylbutyric acid | - | 0 6 | ||
| prenyl acetate | - | 0 6 | balsamic, banana, fresh, fruity, heliotrope, jasmine, ripe, sweet | |
| quinoline | - | 0 9 | earthy, medicinal, musty, rubbery, tobacco | |
| terpinyl acetate | - | 0 9 | bergamot, citrus, herbal, lavender, lime | |
| vanillic acid | - | 0 6 | beany, brown, creamy, dairy, milky, phenolic, powdery, sweet, vanilla | |
| citronellal natural | - | -0.9091 7 | sweet, dry, floral, herbal, waxy, aldehydic, citrus | |
| 2-cyclohexylpropanal | - | -0.9091 7 | natural, fresh, green, dusty, fruity | |
| hydroxycitronellal | - | -0.9091 7 | floral, green, lily, melon, sweet, tropical, waxy | |
| bourgeonal | - | -1.8182 7 | cyclamen, floral, fresh, sweet, watery | |
| florhydral | - | -1.8182 7 | floral, green, muguet, linden_flower, lily_of_the_valley, fresh | |
| 7-methoxycitronellal | - | -1.8182 7 | fresh, melon, floral, lily, sweet |
1.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.
2.) Halperin Kuhns, V. L., Sanchez, J., Sarver, D. C., Khalil, Z., Rajkumar, P., Marr, K. A., & Pluznick, J. L. (2019). Characterizing novel olfactory receptors expressed in the murine renal cortex. American Journal of Physiology-Renal Physiology, 317(1), F172-F186.
3.) YOSHIFUMI FUJITA, TOMOKO TAKAHASHI, AKIKO SUZUKI, KAYO KAWASHIMA, FUTOSHI NARA & RYUTA KOISHI (2007) Deorphanization of Dresden G Protein-Coupled Receptor for an Odorant Receptor, Journal of Receptors and Signal Transduction, 27:4, 323-334, DOI: 10.1080/10799890701534180
4.) Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, et al. () Identification of Odorant-Receptor Interactions by Global Mapping of the Human Odorome. PLoS ONE 9(4): e93037. doi:10.1371/journal.pone.0093037
5.) Pierre Chatelain, Alex Veithen, Francoise Wilkin, and Magali Philippeau Deorphanization and Characterization of Human Olfactory Receptors in Heterologous Cells Chem Biodivers. 2014 Nov;11(11):1764-81. doi: 10.1002/cbdv.201400083. PMID: 25408322.
6.) Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD. Odor coding by a Mammalian receptor repertoire. Sci Signal. 2009 Mar 3;2(60):ra9. doi: 10.1126/scisignal.2000016. PMID: 19261596; PMCID: PMC2774247.
7.) Aya Kato, Naoko Saito, Etsuji Wakisaka (2016) Method for searching for malodor control agent, malodor control agent, and malodor control method. US9526680B2
8.) Aya Kato, Naoko Saito (2018) Search method for odor control agent JP6422665B2
9.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821
10.) Geithe, C.; Andersen, G.; Malki, A.; Krautwurst, D. A butter aroma recombinate activates human class-I odorant receptors. J. Agric. Food Chem. 2015, 63, 9410–9420.