OR2A25

Olfactory Receptor family 2 subfamily A member 25.

Estimated Expression: 100% of the population.

Expression estimate based on data from Verbeurgt et al (2014).

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MGGNQTSITE FLLLGFPIGP RIQMLLFGLF SLFYIFILLG NGTILGLISL DSRLHTPMYF FLSHLAVVDI ACACSTVPQM LVNLLHPAKP ISFAGCMTQM 

       110        120        130        140        150        160        170        180        190        200 
FLFLSFAHTE CLLLVVMSYD RYVAICHPLR YSTIMTWKVC ITLALTSWIL GVLLALVHLV LLLPLSFCGP QKLNHFFCEI MAVLKLACAD THINEVMVLA 

       210        220        230        240        250        260        270        280        290        300 
GAVSVLVGAF FSTVISYVHI LCAILKIQSG EGCQKAFSIC SSHLCVVGLF YGTAIIMYVE PQYESPKEQK KYLLLFHSLF NPMLNPLIYS LRNKEVQGTL 

       310 
KRMLEKKRTS

Transmembrane Helices:

  TMR7     TMR6     TMR5     TMR4     TMR3     TMR2     TMR1   


K Q E K       E   I H T D     L L   S I P K      L L  I R P G  
 L Y K   Y Q P E   V E N   V L H V   G A F    N V L    L M Q   
H F L L   V Y M   A L V M   L A L   Q T M C  M Q P V  L G F L  
 F L S   I I A T   V A G   L V G L   L F M    T S C    L S F   
L M P N   G Y F   V L V S   I W S   F S L F  A C A I  F I Y F  
 L P N   L G V V   F A G   T L A L   T H A    D V V    L L I   
    Y I   C L H   V T S F   T I C   L L C E  A L H S  T G N G  
         S S C I   Y S I   V K W T   V V L    L F F    G L I   
          S F A   L I H V           D Y S M  Y M P T  L S I L  
         K Q C G   I A C             V Y R                 D   
                    I K L           H C I A                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards

Odorant	EC₅₀	Adjusted Top	Aroma Notes
peony acetonitrile	-5.35 ¹	8 ¹	peony, floral, geranium, grapefruit, fresh
(S)-(-)-citronellol	-4.55 ¹	10 ¹	citrus, fatty, floral, fruity, green, leathery, rose, sweet, terpenic, waxy
rosyfolia	-4.959 ²	-
geraniol	-4.85 ¹	-	citrus, floral, fruity, rose, sweet, waxy
geranyl acetate	-8.06 ³	2.2637 ³	floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
mefrosol	-4.70 ¹	-	floral, geranium, green, honey, lily, muguet, fresh, rose, tropical
(R)-(+)-citronellol	-4.55 ¹	-	citronella, floral, leafy, oily, petal, rose
citrus propanol	-4.52 ¹	-	fresh, sweet, clean, citrus, rose, warm, herbal
quinoline	-6 ⁴	2.2667 ⁴	earthy, medicinal, musty, rubbery, tobacco
linalool	-2.06 ⁴	0.5833 ⁴	blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
rosabloom	-	(agonist) ²
allyl phenylacetate	-	0 ⁴	honey, fruity, rummy
n-amyl alcohol	-	0 ⁴	fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
amyl hexanoate	-	0 ⁴	sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone	-	0 ⁴	animal, musky
l-arabinose	-	0 ⁴
benzene	-	0 ⁴	gasoline, phenolic, solvent, cinnamon
butyl formate	-	0 ⁴	fruity, plum, rummy, brandy
butyric acid	-	0 ⁴	sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone	-	0 ⁴	bready, caraway, minty, spicy
citral	-	0 ⁴	sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coffee difuran	-	0 ⁴	cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin	-	0 ⁴	coumarinic, hay, sweet, tonka
beta-damascone	-	0 ⁴	berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal	-	0 ⁴	sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide	-	0 ⁴	sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT	-	0 ⁴
2-ethyl fenchol	-	0 ⁴	camphorous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin	-	0 ⁴	sweet, creamy, vanilla, caramellic
eugenol	-	0 ⁴	clove, spicy, sweet, woody
eugenyl acetate	-	0 ⁴	carnation, clove, floral, fresh, malty, spicy, sweet, woody
helional	-	0 ⁴	cyclamen, fresh, green, hay, ozone, watery
2-heptanone	-	0 ⁴	banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
(Z)-3-hexen-1-ol	-	0 ⁴	fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine	-	0 ⁴	cheesy, fishy
d-limonene	-	0 ⁴	citrus, orange, fresh, sweet
lyral	-	0 ⁴	aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(1S,2R,5S)-(+)-menthol	-	0 ⁴	cooling, mentholic, minty, fresh, sweet, herbal
methyl eugenol	-	0 ⁴	carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide	-	0 ⁴	sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
nonanal	-	0 ⁴	waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol	-	0 ⁴	aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol	-	0 ⁴	sulfurous
1-octanol	-	0 ⁴	aldehydic, green, mushroom, orange, rose, waxy
octyl octanoate	-	0 ⁴	coconut, oily, fruity
pelargonic acid	-	0 ⁴	cheesy, dairy, dirty, waxy
propanal	-	0 ⁴	alcoholic, cocoa, earthy, nutty, whisky, winey
propionic acid	-	0 ⁴	acidic, cheesy, pungent, vinegar
pyrazine	-	0 ⁴	pungent, sweet, corn, roasted, hazelnut, barley
sotolone	-	0 ⁴	sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate	-	0 ⁴	bergamot, citrus, herbal, lavender, lime
methyl salicylate	-	-0.2333 ⁴	minty, wintergreen

1.) Roger Emter, Christel Merillat, Fiona Buchli, Felix Flachsmann, Andreas Natsch. Decoding human olfaction by high heterologous expression of odorant receptors detecting signature odorants. Current Biology, October 10, 2025

2.) Roger EmterAndreas Natsch Modified olfactory receptors WO2024126820A1

3.) Dunkel, A.; Steinhaus, M.; Kotthoff, M.; Nowak, B.; Krautwurst, D.; Schieberle, P.; Hofmann, T. Nature’s chemical signatures in human olfaction: A foodborne perspective for future biotechnology. Angew. Chem. Int. Ed. Engl. 2014, 53, 7124–7143.

4.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

Prot.	Sim.	Expr.	2.53	3.29	3.32	3.33	3.36	3.37	3.40	3.41	4.53	4.56	4.57	4.60	45.49	45.51	45.52	45.53	5.39	5.42	5.43	5.46	5.47	6.48	6.51	6.55	6.59	7.38	7.39	7.41	7.42
OR2A25	100	100%	C	M	F	L	A	H	C	L	G	L	A	H	F	E	I	M	V	G	A	V	L	Y	A	Y	Q	L	L	H	S
OR2A1	84		Y	T	C	L	G	H	C	L	G	L	A	H	F	E	I	L	I	A	C	F	L	F	A	Y	K	F	L	Y	S
OR2A5	83	100%	Y	T	Y	M	A	H	C	L	G	L	A	H	F	E	I	L	I	A	S	I	L	F	A	Y	K	S	L	Y	S
OR5B3	83	88%	Y	M	F	V	A	T	N	Y	G	N	A	H	F	D	I	P	L	V	V	N	I	Y	I	Y	S	P	V	Y	T
OR10T2	83	65%	Y	L	F	L	A	C	C	L	G	I	A	A	F	D	M	A	L	L	S	V	I	Y	A	Y	K	A	V	Y	T
OR2A4	83		Y	T	F	S	A	V	C	L	G	L	S	H	F	E	I	L	V	G	A	G	L	Y	A	Y	R	L	L	H	S
OR2A7	83		Y	T	F	S	A	V	C	L	G	L	S	H	F	E	I	L	V	G	A	G	L	Y	A	Y	R	L	L	H	S
OR1S1	82	73%	S	M	S	I	V	V	N	L	S	I	A	H	F	D	L	A	L	V	G	V	I	Y	I	Y	S	A	V	F	T
OR5B21	81	100%	Y	F	F	V	A	T	C	Y	G	N	A	H	F	D	I	P	V	V	A	N	V	Y	I	Y	N	S	V	Y	T
OR10S1	81	92%	L	L	F	H	A	S	C	F	G	H	A	H	F	D	I	P	M	S	I	V	A	Y	P	Y	R	A	V	Y	T
OR10W1	81	100%	Y	M	F	I	G	S	C	F	G	L	S	L	F	D	V	P	V	A	A	A	I	Y	C	Y	S	S	L	Y	T
OR14L1	81		Y	A	F	M	A	T	V	A	G	C	G	H	F	N	I	P	V	F	G	L	V	M	G	Y	I	S	A	Y	T
OR2AG2	80	100%	F	M	A	L	G	S	D	L	A	I	A	H	L	E	I	P	I	T	G	F	L	Y	A	Y	S	S	V	Y	T
OR5AS1	80	73%	C	M	F	A	A	D	C	L	G	T	S	H	F	D	I	P	L	L	C	I	Q	Y	L	Y	T	A	V	Y	T
OR8U9	80	80%	Y	L	F	L	M	T	C	L	S	V	A	H	Y	D	D	M	I	C	A	M	F	Y	L	Y	S	S	V	Y	T
OR10K2	80	96%	Y	M	F	L	G	C	S	F	G	V	A	I	F	D	I	A	I	L	C	V	L	Y	A	Y	Q	S	V	Y	T
OR8B2	80	88%	Y	L	F	L	V	I	C	Y	G	G	A	H	L	D	I	L	V	V	V	N	I	F	A	Y	Y	S	V	Y	T
OR8B3	80	88%	Y	L	F	L	V	I	C	Y	G	G	A	H	L	D	I	L	V	V	V	N	I	F	A	Y	Y	S	V	Y	T

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