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Olfactory Receptor family 2 subfamily A member 25.

Sequence:

        10         20         30         40         50         60         70         80         90        100 
MGGNQTSITE FLLLGFPIGP RIQMLLFGLF SLFYIFILLG NGTILGLISL DSRLHTPMYF FLSHLAVVDI ACACSTVPQM LVNLLHPAKP ISFAGCMTQM 

       110        120        130        140        150        160        170        180        190        200 
FLFLSFAHTE CLLLVVMSYD RYVAICHPLR YSTIMTWKVC ITLALTSWIL GVLLALVHLV LLLPLSFCGP QKLNHFFCEI MAVLKLACAD THINEVMVLA 

       210        220        230        240        250        260        270        280        290        300 
GAVSVLVGAF FSTVISYVHI LCAILKIQSG EGCQKAFSIC SSHLCVVGLF YGTAIIMYVE PQYESPKEQK KYLLLFHSLF NPMLNPLIYS LRNKEVQGTL 

       310 
KRMLEKKRTS

Transmembrane Helices:

  TMR1     TMR2     TMR3     TMR4     TMR5     TMR6     TMR7   

I R P G        L  G A F S     L L   I H T D     P E   Q E K P  
 L M Q    N V L    T M C   V L H V   V E N   V Y M I   Y K K   
L G F L  M Q P V  L F M Q   L A L   A L V M   I A T   F L L L  
 L S F    T S C    S L F   L V G L   V A G   G Y F L   L S H   
F I Y F  A C A I  T H A F   I W S   V L V S   G V V   M P N F  
 L L I    D V V    L C E   T L A L   F A G   C L H S   P N L   
T G N G  A L H S  V V L L   T I C   V T S F   S C I   S Y I L  
 G L I    L F F    Y S M   V K W T   Y S I   S F A K       L   
  S I L  Y M P T  V Y R D           L I H V   Q C G            
                   C I A             I A C   E G S Q           
                        H               K L                    
    

    UniProt | I-TASSER | AlphaFold | HORDE | GeneCards
Odorant EC50 Adjusted Top Antagonist? Aroma Notes
geranyl acetate -8.06 1 2.2637 1  floral, rose, lavender, green, waxy, herbal, cooling, oily, soapy, citrus, winey, rummy
quinoline -6 1 2.2667 2  earthy, medicinal, musty, rubbery, tobacco
linalool -2.06 3 0.5833 3  blueberry, bois_de_rose, citrus, floral, green, rose, sweet, woody
allyl phenylacetate - 0 2  honey, fruity, rummy
amyl hexanoate - 0 2  sweet, green, fruity, estery, pineapple, apple, pear, fatty, waxy, cognac, melon
androstenone - 0 2  animal, musky
l-arabinose - 0 2  
benzene - 0 2  
butyl formate - 0 2  fruity, plum, rummy, brandy
butyric acid - 0 2  sharp, acetic, cheesy, buttery, fruity, dairy, creamy
(S)-(+)-carvone - 0 2  bready, caraway, minty, spicy
citral - 0 2  sharp, lemon, sweet, fresh, juicy, lemon_peel, tart, green, citrus, lime, woody, herbal
coffee difuran - 0 2  cabbage, chicken, coffee, meaty, onion, roasted, sulfurous, cocoa, earthy, fungal, mild, mushroom, nutty
coumarin - 0 2  coumarinic, hay, sweet, tonka
beta-damascone - 0 2  berry, currant, floral, fruity, honey, plum, rose, tobacco
decanal - 0 2  sweet, aldehydic, waxy, orange_peel, citrus, floral
dimethyl disulfide - 0 2  sulfurous, vegetable, cabbage, onion, malty, creamy
2,4-DNT - 0 2  
2-ethyl fenchol - 0 2  camphoraceous, earthy, humus, mushroom, musty, patchouli, potato, rooty, tea
ethyl vanillin - 0 2  sweet, creamy, vanilla, caramellic
eugenol - 0 2  clove, spicy, sweet, woody
eugenyl acetate - 0 2  carnation, clove, floral, fresh, malty, spicy, sweet, woody
helional - 0 2  cyclamen, fresh, green, hay, ozone, watery
2-heptanone - 0 2  banana, cheesy, coconut, creamy, fruity, green, herbal, ketonic, spicy, sweet, waxy, woody
(Z)-3-hexen-1-ol - 0 2  fresh, green, grassy, foliage, vegetable, herbal, oily, melon_rind, pungent, lettuce
isobutylamine - 0 2  cheesy, fishy
d-limonene - 0 2  citrus, orange, fresh, sweet
lyral - 0 2  aquatic, clean, cyclamen, floral, muguet, rhubarb, watery, waxy, woody
(1S,2R,5S)-(+)-menthol - 0 2  cooling, mentholic, minty
methyl eugenol - 0 2  carnation, cinnamon, clove, fresh, spicy, sweet, warm
methyl furfuryl disulfide - 0 2  sulfurous, coffee, roasted, alliaceous, meaty, liver, onion, garlic, eggy
nonanal - 0 2  waxy, aldehydic, rose, fresh, orris, orange_peel, fatty, peely
1-nonanol - 0 2  aldehydic, citrus, clean, dusty, fatty, floral, fresh, oily, orange, rose, sweet, tart, waxy, wet
octanethiol - 0 2  sulfurous
1-octanol - 0 2  aldehydic, green, mushroom, orange, rose, waxy
octyl octanoate - 0 2  coconut, oily, fruity
pelargonic acid - 0 2  cheesy, dairy, dirty, waxy
pentanol - 0 2  fusel, oily, sweet, balsamic, pungent, fermented, bready, yeasty, winey, solvent
propanal - 0 2  alcoholic, cocoa, earthy, nutty, whiskey, winey
propionic acid - 0 2  acidic, cheesy, pungent, vinegar
pyrazine - 0 2  pungent, sweet, corn, roasted, hazelnut, barley
sotolone - 0 2  sweet, caramellic, maple, sugar, burnt_sugar, coffee, brown_sugar, cotton_candy
terpinyl acetate - 0 2  bergamot, citrus, herbal, lavender, lime
methyl salicylate - -0.2333 2  minty, wintergreen

1.) Mainland JD, Li YR, Zhou T, Liu WL, Matsunami H. Human olfactory receptor responses to odorants. Sci Data. 2015 Feb 3;2:150002. doi: 10.1038/sdata.2015.2. PMID: 25977809; PMCID: PMC4412152.

2.) Adipietro KA, Mainland JD, Matsunami H (2012) Functional Evolution of Mammalian Odorant Receptors. PLoS Genet 8(7): e1002821. doi:10.1371/ journal.pgen.1002821

3.) C. Trimmer, A. Keller, N. R. Murphy, L. L. Snyder, J. R. Willer, M. H. Nagai, N. Katsanis, L. B. Vosshall, H. Matsunami, and J. D. Mainland Genetic variation across the human olfactory receptor repertoire alters odor perception PNAS | May 7, 2019 | vol. 116 | no. 19 | 9475–9480
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